The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Transcription factors with Perturb-seq knockdown data for XPO7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XPO7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XPO7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:20,352,955–20,355,223 | 1564.7 kb | Distal (>10kb) Multiome HiCAR | 316 | |
| chr8:21,724,408–21,725,088 | 195.1 kb | Distal (>10kb) Multiome | 30 | |
| chr8:21,740,783–21,741,352 | 178.7 kb | Distal (>10kb) Multiome | 42 | |
| chr8:21,782,177–21,783,108 | 137.1 kb | Distal (>10kb) Multiome | 145 | |
| chr8:21,784,384–21,784,867 | 135.2 kb | Distal (>10kb) Multiome | 246 | |
| chr8:21,788,264–21,790,181 | 130.7 kb | Distal (>10kb) Multiome | 307 | |
| chr8:21,812,040–21,812,512 | 107.5 kb | Distal (>10kb) Multiome | 199 | |
| chr8:21,915,390–21,915,806 | 3.9 kb | Proximal (<10kb) | 183 | |
| chr8:21,918,240–21,920,671 | 142 bp | At TSS Multiome | 727 | |
| chr8:22,009,978–22,010,924 | 90.6 kb | Distal (>10kb) Multiome | 885 | |
| chr8:22,024,029–22,025,514 | 105.5 kb | Distal (>10kb) Multiome | 508 | |
| chr8:22,036,665–22,037,480 | 117.2 kb | Distal (>10kb) Multiome | 457 | |
| chr8:22,039,647–22,043,111 | 120.3 kb | Distal (>10kb) Multiome | 407 | |
| chr8:22,047,856–22,051,849 | 129.5 kb | Distal (>10kb) Multiome | 566 | |
| chr8:22,052,727–22,057,283 | 134.2 kb | Distal (>10kb) Multiome | 541 | |
| chr8:22,066,266–22,067,293 | 147.1 kb | Distal (>10kb) Multiome | 612 | |
| chr8:22,069,764–22,070,311 | 150.3 kb | Distal (>10kb) Multiome | 85 | |
| chr8:22,089,006–22,089,746 | 169.4 kb | Distal (>10kb) Multiome | 562 | |
| chr8:22,095,301–22,095,802 | 175.8 kb | Distal (>10kb) Multiome | 199 | |
| chr8:22,108,625–22,110,515 | 189.8 kb | Distal (>10kb) Multiome | 907 | |
| chr8:22,129,779–22,131,071 | 210.7 kb | Distal (>10kb) Multiome HiCAR | 440 | |
| chr8:22,137,231–22,137,850 | 217.8 kb | Distal (>10kb) Multiome HiCAR | 531 | |
| chr8:22,140,995–22,142,545 | 222.2 kb | Distal (>10kb) Multiome | 753 | |
| chr8:22,156,517–22,157,091 | 237.1 kb | Distal (>10kb) Multiome | 215 | |
| chr8:22,164,354–22,165,830 | 245.3 kb | Distal (>10kb) Multiome | 672 | |
| chr8:22,176,636–22,177,193 | 257.3 kb | Distal (>10kb) Multiome | 91 | |
| chr8:22,188,487–22,189,031 | 269.1 kb | Distal (>10kb) Multiome | 334 |
Genomic view of the XPO7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.