Enables RNA uridylyltransferase activity. Involved in RNA metabolic process; stem cell population maintenance; and transposable element silencing by mRNA destabilization. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleolus. Implicated in liver benign neoplasm. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TUT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:52,365,194–52,367,305 | 186.7 kb | Distal (>10kb) Multiome | 969 | |
| chr1:52,368,430–52,369,016 | 184.5 kb | Distal (>10kb) Multiome | 340 | |
| chr1:52,403,732–52,405,027 | 148.5 kb | Distal (>10kb) Multiome | 789 | |
| chr1:52,550,519–52,550,830 | 2.2 kb | Proximal (<10kb) | 159 | |
| chr1:52,552,164–52,554,055 | 317 bp | At TSS Multiome | 955 | |
| chr1:52,554,397–52,555,330 | 1.3 kb | Proximal (<10kb) | 85 | |
| chr1:52,602,249–52,602,924 | 49.5 kb | Distal (>10kb) Multiome | 267 | |
| chr1:52,632,811–52,633,791 | 80.2 kb | Distal (>10kb) Multiome | 269 | |
| chr1:52,662,669–52,663,405 | 110.0 kb | Distal (>10kb) Multiome HiCAR | 285 | |
| chr1:52,697,629–52,698,936 | 145.3 kb | Distal (>10kb) Multiome | 997 | |
| chr1:52,702,879–52,703,689 | 150.1 kb | Distal (>10kb) Multiome | 872 | |
| chr1:52,726,263–52,726,954 | 173.4 kb | Distal (>10kb) Multiome | 681 | |
| chr1:52,842,499–52,843,778 | 289.7 kb | Distal (>10kb) Multiome | 687 |
Genomic view of the TUT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.