This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRIM27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:28,657,863–28,658,336 | 265.8 kb | Distal (>10kb) Multiome | 477 | |
| chr6:28,682,403–28,683,572 | 241.1 kb | Distal (>10kb) Multiome | 119 | |
| chr6:28,709,835–28,710,861 | 213.7 kb | Distal (>10kb) Multiome | 486 | |
| chr6:28,758,091–28,758,572 | 165.6 kb | Distal (>10kb) Multiome | 538 | |
| chr6:28,766,057–28,766,737 | 157.4 kb | Distal (>10kb) Multiome | 45 | |
| chr6:28,775,686–28,777,151 | 147.4 kb | Distal (>10kb) Multiome | 330 | |
| chr6:28,789,668–28,790,123 | 134.1 kb | Distal (>10kb) Multiome | 466 | |
| chr6:28,795,706–28,796,323 | 127.8 kb | Distal (>10kb) Multiome | 598 | |
| chr6:28,837,417–28,839,268 | 85.0 kb | Distal (>10kb) Multiome | 927 | |
| chr6:28,863,417–28,864,476 | 60.0 kb | Distal (>10kb) Multiome | 894 | |
| chr6:28,865,612–28,867,050 | 57.6 kb | Distal (>10kb) Multiome | 785 | |
| chr6:28,895,454–28,897,321 | 27.6 kb | Distal (>10kb) Multiome | 1132 | |
| chr6:28,923,043–28,924,600 | 116 bp | At TSS Multiome | 1012 | |
| chr6:28,927,792–28,928,410 | 3.9 kb | Proximal (<10kb) | 33 | |
| chr6:28,940,313–28,941,870 | 16.9 kb | Distal (>10kb) Multiome | 807 | |
| chr6:28,943,542–28,944,680 | 19.8 kb | Distal (>10kb) Multiome | 783 | |
| chr6:28,980,730–28,982,814 | 58.4 kb | Distal (>10kb) Multiome | 914 | |
| chr6:28,984,693–28,985,963 | 61.7 kb | Distal (>10kb) Multiome | 553 | |
| chr6:28,988,531–28,989,268 | 64.9 kb | Distal (>10kb) Multiome | 290 | |
| chr6:29,014,571–29,016,258 | 91.0 kb | Distal (>10kb) Multiome | 293 | |
| chr6:29,016,579–29,017,058 | 93.1 kb | Distal (>10kb) Multiome | 611 |
Genomic view of the TRIM27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.