TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
Transcription factors with Perturb-seq knockdown data for TRAM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:52,284,162–52,285,425 | 292.2 kb | Distal (>10kb) Multiome | 958 | |
| chr6:52,307,052–52,307,665 | 269.8 kb | Distal (>10kb) Multiome | 164 | |
| chr6:52,325,495–52,326,616 | 251.0 kb | Distal (>10kb) Multiome | 519 | |
| chr6:52,361,573–52,363,274 | 215.0 kb | Distal (>10kb) Multiome | 796 | |
| chr6:52,413,171–52,413,920 | 163.5 kb | Distal (>10kb) Multiome HiCAR | 46 | |
| chr6:52,419,778–52,421,057 | 156.8 kb | Distal (>10kb) Multiome HiCAR | 913 | |
| chr6:52,570,669–52,571,485 | 5.6 kb | Proximal (<10kb) | 60 | |
| chr6:52,576,332–52,577,737 | 68 bp | At TSS Multiome | 1007 | |
| chr6:52,598,101–52,598,732 | 21.3 kb | Distal (>10kb) Multiome | 684 | |
| chr6:52,664,088–52,665,240 | 87.3 kb | Distal (>10kb) Multiome | 857 | |
| chr6:52,670,570–52,671,575 | 94.0 kb | Distal (>10kb) Multiome | 843 | |
| chr6:52,675,296–52,676,107 | 98.5 kb | Distal (>10kb) Multiome | 62 | |
| chr6:52,855,940–52,856,582 | 279.2 kb | Distal (>10kb) Multiome | 166 | |
| chr6:52,861,065–52,861,720 | 284.4 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the TRAM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.