Enables voltage-gated chloride channel activity. Predicted to be involved in sensory perception of salty taste. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:53,865,880–53,866,753 | 294.4 kb | Distal (>10kb) Multiome | 532 | |
| chr19:53,866,887–53,869,891 | 293.0 kb | Distal (>10kb) Multiome | 993 | |
| chr19:53,878,918–53,880,011 | 281.1 kb | Distal (>10kb) Multiome | 561 | |
| chr19:53,881,744–53,882,458 | 278.5 kb | Distal (>10kb) Multiome | 435 | |
| chr19:53,889,715–53,890,286 | 270.6 kb | Distal (>10kb) Multiome | 322 | |
| chr19:53,898,176–53,899,412 | 261.7 kb | Distal (>10kb) Multiome | 212 | |
| chr19:53,907,868–53,908,722 | 252.4 kb | Distal (>10kb) Multiome | 276 | |
| chr19:53,941,849–53,943,229 | 218.2 kb | Distal (>10kb) Multiome | 240 | |
| chr19:53,957,309–53,957,858 | 203.1 kb | Distal (>10kb) Multiome | 97 | |
| chr19:53,977,539–53,979,011 | 182.2 kb | Distal (>10kb) Multiome | 412 | |
| chr19:53,979,770–53,982,403 | 179.3 kb | Distal (>10kb) Multiome | 530 | |
| chr19:53,982,560–53,983,015 | 177.8 kb | Distal (>10kb) Multiome | 119 | |
| chr19:54,095,628–54,096,220 | 64.7 kb | Distal (>10kb) Multiome | 457 | |
| chr19:54,102,597–54,103,302 | 57.8 kb | Distal (>10kb) Multiome | 703 | |
| chr19:54,114,870–54,116,009 | 45.1 kb | Distal (>10kb) Multiome | 911 | |
| chr19:54,136,562–54,138,683 | 23.2 kb | Distal (>10kb) Multiome | 751 | |
| chr19:54,159,030–54,160,865 | 783 bp | At TSS Multiome | 793 | |
| chr19:54,161,897–54,162,738 | 1.8 kb | Proximal (<10kb) Multiome | 233 | |
| chr19:54,164,508–54,165,013 | 4.2 kb | Proximal (<10kb) Multiome | 183 | |
| chr19:54,168,389–54,168,795 | 7.7 kb | Proximal (<10kb) | 355 | |
| chr19:54,172,536–54,173,532 | 12.5 kb | Distal (>10kb) Multiome | 397 | |
| chr19:54,178,635–54,178,792 | 5.5 kb | Proximal (<10kb) | 158 | |
| chr19:54,179,952–54,180,330 | 6.8 kb | Proximal (<10kb) | 177 | |
| chr19:54,188,192–54,192,172 | 29.3 kb | Distal (>10kb) Multiome | 979 | |
| chr19:54,200,383–54,201,351 | 40.2 kb | Distal (>10kb) Multiome | 891 | |
| chr19:54,208,780–54,209,556 | 48.8 kb | Distal (>10kb) Multiome | 358 | |
| chr19:54,231,547–54,232,136 | 71.2 kb | Distal (>10kb) Multiome | 471 | |
| chr19:54,420,287–54,421,161 | 260.2 kb | Distal (>10kb) Multiome | 334 | |
| chr19:54,430,381–54,431,285 | 270.4 kb | Distal (>10kb) Multiome | 240 | |
| chr19:54,448,346–54,449,853 | 288.6 kb | Distal (>10kb) Multiome | 959 | |
| chr19:54,462,469–54,465,494 | 303.3 kb | Distal (>10kb) Multiome | 1004 |
Genomic view of the TMC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.