Enables transmembrane transporter binding activity. Involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TCAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:143,836,472–143,837,054 | 65.5 kb | Distal (>10kb) Multiome HiCAR | 74 | |
| chr7:143,881,743–143,883,200 | 19.4 kb | Distal (>10kb) Multiome | 587 | |
| chr7:143,883,508–143,884,107 | 1.2 kb | Proximal (<10kb) | 47 | |
| chr7:143,884,257–143,884,577 | 693 bp | At TSS | 12 | |
| chr7:143,884,711–143,885,690 | 16.8 kb | Distal (>10kb) Multiome | 292 | |
| chr7:143,886,034–143,886,386 | 763 bp | At TSS | 29 | |
| chr7:143,892,526–143,892,944 | 7.3 kb | Proximal (<10kb) | 288 | |
| chr7:143,900,208–143,900,709 | 1.5 kb | Proximal (<10kb) | 371 | |
| chr7:143,901,218–143,902,937 | 54 bp | At TSS Multiome | 1006 | |
| chr7:143,906,770–143,907,540 | 4.6 kb | Proximal (<10kb) | 430 |
Genomic view of the TCAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.