This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for SYNC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYNC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYNC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:32,437,702–32,438,502 | 264.5 kb | Distal (>10kb) Multiome | 85 | |
| chr1:32,439,697–32,440,223 | 262.9 kb | Distal (>10kb) Multiome | 40 | |
| chr1:32,464,697–32,465,552 | 237.7 kb | Distal (>10kb) Multiome | 408 | |
| chr1:32,500,363–32,501,049 | 202.0 kb | Distal (>10kb) Multiome | 540 | |
| chr1:32,520,498–32,520,989 | 182.1 kb | Distal (>10kb) Multiome | 384 | |
| chr1:32,539,285–32,540,081 | 163.0 kb | Distal (>10kb) Multiome | 434 | |
| chr1:32,540,505–32,541,033 | 161.9 kb | Distal (>10kb) Multiome | 172 | |
| chr1:32,611,983–32,612,668 | 90.5 kb | Distal (>10kb) Multiome | 560 | |
| chr1:32,643,807–32,644,727 | 58.6 kb | Distal (>10kb) Multiome | 70 | |
| chr1:32,650,248–32,651,874 | 51.7 kb | Distal (>10kb) Multiome | 1164 | |
| chr1:32,702,459–32,702,854 | at TSS | At TSS | 234 | |
| chr1:32,707,623–32,707,920 | 4.9 kb | Proximal (<10kb) | 22 | |
| chr1:32,709,059–32,709,375 | 6.3 kb | Proximal (<10kb) | 61 | |
| chr1:32,712,054–32,712,688 | 9.6 kb | Proximal (<10kb) Multiome | 645 | |
| chr1:32,715,926–32,717,303 | 14.0 kb | Distal (>10kb) Multiome | 551 | |
| chr1:32,736,558–32,737,765 | 34.3 kb | Distal (>10kb) Multiome | 507 | |
| chr1:32,753,606–32,755,507 | 51.2 kb | Distal (>10kb) Multiome | 565 | |
| chr1:32,758,502–32,759,280 | 56.1 kb | Distal (>10kb) Multiome | 144 | |
| chr1:32,765,137–32,765,925 | 62.9 kb | Distal (>10kb) Multiome HiCAR | 122 | |
| chr1:32,772,938–32,773,451 | 70.4 kb | Distal (>10kb) Multiome HiCAR | 441 | |
| chr1:32,816,876–32,818,654 | 114.8 kb | Distal (>10kb) Multiome | 1138 | |
| chr1:32,870,570–32,871,148 | 168.0 kb | Distal (>10kb) Multiome | 182 | |
| chr1:32,886,388–32,887,030 | 183.9 kb | Distal (>10kb) Multiome | 917 | |
| chr1:32,892,705–32,893,946 | 190.4 kb | Distal (>10kb) Multiome | 444 | |
| chr1:32,901,143–32,901,775 | 198.7 kb | Distal (>10kb) Multiome | 393 | |
| chr1:32,963,782–32,965,243 | 262.1 kb | Distal (>10kb) Multiome | 882 | |
| chr1:32,972,824–32,973,439 | 270.3 kb | Distal (>10kb) Multiome | 489 |
Genomic view of the SYNC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.