SULF2

sulfatase 2 | HSULF-2, KIAA1247, SULF-2

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

Member of: DE-4 Developmental clusters: GC6

Biological processes 56 terms

Golgi apparatus (GO:0005794)Golgi stack (GO:0005795)N-acetylglucosamine-6-sulfatase activity (GO:0008449)N-acetylglucosamine-6-sulfatase activity (GO:0008449)N-acetylglucosamine-6-sulfatase activity (GO:0008449)N-acetylglucosamine-6-sulfatase activity (GO:0008449)arylsulfatase activity (GO:0004065)arylsulfatase activity (GO:0004065)arylsulfatase activity (GO:0004065)bone development (GO:0060348)bone development (GO:0060348)calcium ion binding (GO:0005509)cartilage development (GO:0051216)cartilage development (GO:0051216)cell surface (GO:0009986)cell surface (GO:0009986)cell surface (GO:0009986)chondrocyte development (GO:0002063)chondrocyte development (GO:0002063)embryonic skeletal system development (GO:0048706)embryonic skeletal system development (GO:0048706)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)esophagus smooth muscle contraction (GO:0014846)esophagus smooth muscle contraction (GO:0014846)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)glial cell-derived neurotrophic factor receptor signaling pathway (GO:0035860)glial cell-derived neurotrophic factor receptor signaling pathway (GO:0035860)glomerular basement membrane development (GO:0032836)glomerular basement membrane development (GO:0032836)glomerular filtration (GO:0003094)glomerular filtration (GO:0003094)heparan sulfate proteoglycan catabolic process (GO:0030200)heparan sulfate proteoglycan metabolic process (GO:0030201)heparan sulfate proteoglycan metabolic process (GO:0030201)heparan sulfate proteoglycan metabolic process (GO:0030201)innervation (GO:0060384)innervation (GO:0060384)kidney development (GO:0001822)kidney development (GO:0001822)negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of Wnt signaling pathway (GO:0030177)positive regulation of Wnt signaling pathway (GO:0030177)positive regulation of endothelin production (GO:1904472)positive regulation of vascular endothelial growth factor production (GO:0010575)positive regulation of vascular endothelial growth factor production (GO:0010575)positive regulation of vascular endothelial growth factor production (GO:0010575)protein binding (GO:0005515)sulfuric ester hydrolase activity (GO:0008484)

Expression (TPM)

TFs regulating SULF2 0 TFs

Transcription factors with Perturb-seq knockdown data for SULF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SULF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SULF2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SULF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:47,501,324–47,502,272	283.6 kb	Distal (>10kb) Multiome	1052
chr20:47,761,548–47,762,222	23.7 kb	Distal (>10kb) Multiome	87
chr20:47,783,316–47,783,518	2.0 kb	Proximal (<10kb)	118
chr20:47,784,934–47,785,273	215 bp	At TSS	325
chr20:47,785,376–47,786,125	112 bp	At TSS Multiome	423
chr20:47,786,412–47,786,793	923 bp	At TSS	533
chr20:47,862,561–47,863,436	77.5 kb	Distal (>10kb) Multiome	89
chr20:47,876,376–47,876,884	91.1 kb	Distal (>10kb) Multiome	89
chr20:48,186,863–48,187,530	401.6 kb	Distal (>10kb) Multiome HiCAR	172
chr20:48,275,743–48,276,451	490.5 kb	Distal (>10kb) Multiome HiCAR	162
chr20:48,278,915–48,279,562	493.7 kb	Distal (>10kb) Multiome HiCAR	97
chr20:48,620,328–48,621,446	835.4 kb	Distal (>10kb) Multiome HiCAR	701

Genome Browser

Genomic view of the SULF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.