Enables RNA binding activity. Located in cytosol; nucleolus; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPATS2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPATS2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPATS2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:200,090,238–200,091,621 | 214.7 kb | Distal (>10kb) Multiome | 66 | |
| chr2:200,201,704–200,202,415 | 103.9 kb | Distal (>10kb) Multiome | 128 | |
| chr2:200,203,430–200,204,082 | 102.3 kb | Distal (>10kb) Multiome | 141 | |
| chr2:200,295,938–200,296,365 | 9.6 kb | Proximal (<10kb) | 20 | |
| chr2:200,305,837–200,307,750 | 927 bp | At TSS Multiome | 864 | |
| chr2:200,481,420–200,481,868 | 175.6 kb | Distal (>10kb) Multiome | 350 | |
| chr2:200,509,374–200,510,438 | 204.1 kb | Distal (>10kb) Multiome | 876 | |
| chr2:200,525,770–200,526,701 | 220.1 kb | Distal (>10kb) Multiome | 869 | |
| chr2:200,585,716–200,586,842 | 280.1 kb | Distal (>10kb) Multiome | 627 |
Genomic view of the SPATS2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.