This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for SNX5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:17,679,860–17,683,144 | 286.3 kb | Distal (>10kb) Multiome | 1108 | |
| chr20:17,752,432–17,753,052 | 216.1 kb | Distal (>10kb) Multiome | 60 | |
| chr20:17,938,730–17,940,231 | 29.6 kb | Distal (>10kb) Multiome | 678 | |
| chr20:17,968,085–17,969,639 | 66 bp | At TSS Multiome | 1144 | |
| chr20:17,969,901–17,970,306 | 1.4 kb | Proximal (<10kb) | 306 | |
| chr20:18,032,971–18,033,755 | 64.4 kb | Distal (>10kb) Multiome | 212 | |
| chr20:18,057,257–18,058,052 | 89.1 kb | Distal (>10kb) Multiome | 323 | |
| chr20:18,058,764–18,059,467 | 90.4 kb | Distal (>10kb) Multiome | 393 | |
| chr20:18,101,249–18,101,961 | 132.8 kb | Distal (>10kb) Multiome | 74 | |
| chr20:18,103,190–18,103,994 | 134.9 kb | Distal (>10kb) Multiome | 149 | |
| chr20:18,137,127–18,138,367 | 169.0 kb | Distal (>10kb) Multiome | 1046 |
Genomic view of the SNX5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.