This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for SIPA1L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIPA1L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIPA1L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:232,352,018–232,353,153 | 277.5 kb | Distal (>10kb) Multiome | 118 | |
| chr1:232,556,899–232,558,508 | 72.8 kb | Distal (>10kb) Multiome | 148 | |
| chr1:232,578,687–232,579,194 | 51.1 kb | Distal (>10kb) Multiome | 180 | |
| chr1:232,620,290–232,620,728 | 9.4 kb | Proximal (<10kb) | 303 | |
| chr1:232,623,053–232,623,371 | 6.8 kb | Proximal (<10kb) | 100 | |
| chr1:232,629,319–232,630,977 | 146 bp | At TSS Multiome | 598 | |
| chr1:232,805,253–232,806,244 | 175.4 kb | Distal (>10kb) Multiome | 430 | |
| chr1:232,950,168–232,951,099 | 320.4 kb | Distal (>10kb) Multiome HiCAR | 692 | |
| chr1:233,228,052–233,228,602 | 598.1 kb | Distal (>10kb) Multiome HiCAR | 34 | |
| chr1:233,233,376–233,234,177 | 603.7 kb | Distal (>10kb) Multiome HiCAR | 143 | |
| chr1:233,294,969–233,295,863 | 665.5 kb | Distal (>10kb) Multiome HiCAR | 466 |
Genomic view of the SIPA1L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.