This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SF3B6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SF3B6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SF3B6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:23,925,864–23,928,023 | 149.2 kb | Distal (>10kb) Multiome | 1102 | |
| chr2:23,939,310–23,941,043 | 135.9 kb | Distal (>10kb) Multiome | 856 | |
| chr2:24,009,633–24,010,873 | 66.1 kb | Distal (>10kb) Multiome | 382 | |
| chr2:24,046,941–24,048,071 | 28.9 kb | Distal (>10kb) Multiome | 719 | |
| chr2:24,049,244–24,050,644 | 26.6 kb | Distal (>10kb) Multiome | 554 | |
| chr2:24,075,859–24,077,721 | 302 bp | At TSS Multiome | 1100 | |
| chr2:24,083,513–24,085,355 | 8.0 kb | Proximal (<10kb) Multiome | 1088 | |
| chr2:24,123,015–24,123,986 | 47.1 kb | Distal (>10kb) Multiome | 899 | |
| chr2:24,191,824–24,192,305 | 115.6 kb | Distal (>10kb) Multiome | 68 | |
| chr2:24,280,210–24,280,709 | 204.0 kb | Distal (>10kb) Multiome | 38 | |
| chr2:24,315,559–24,316,125 | 239.4 kb | Distal (>10kb) Multiome | 99 | |
| chr2:24,359,764–24,361,015 | 284.2 kb | Distal (>10kb) Multiome | 909 |
Genomic view of the SF3B6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.