This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SEMA6B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEMA6B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEMA6B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,326,625–4,329,107 | 253.3 kb | Distal (>10kb) Multiome | 567 | |
| chr19:4,342,323–4,344,016 | 238.8 kb | Distal (>10kb) Multiome | 969 | |
| chr19:4,390,525–4,391,068 | 191.1 kb | Distal (>10kb) Multiome | 464 | |
| chr19:4,399,835–4,401,019 | 181.2 kb | Distal (>10kb) Multiome | 828 | |
| chr19:4,402,106–4,403,050 | 179.3 kb | Distal (>10kb) Multiome | 731 | |
| chr19:4,456,541–4,458,172 | 124.0 kb | Distal (>10kb) Multiome | 757 | |
| chr19:4,471,202–4,472,545 | 109.8 kb | Distal (>10kb) Multiome | 715 | |
| chr19:4,474,252–4,474,874 | 107.1 kb | Distal (>10kb) Multiome | 201 | |
| chr19:4,534,817–4,535,416 | 46.5 kb | Distal (>10kb) Multiome | 451 | |
| chr19:4,556,056–4,556,977 | 25.1 kb | Distal (>10kb) Multiome | 259 | |
| chr19:4,581,475–4,581,916 | 16 bp | At TSS Multiome | 358 | |
| chr19:4,584,244–4,584,620 | 2.5 kb | Proximal (<10kb) | 608 | |
| chr19:4,597,380–4,598,540 | 16.4 kb | Distal (>10kb) Multiome | 280 | |
| chr19:4,633,303–4,633,826 | 51.7 kb | Distal (>10kb) Multiome | 500 | |
| chr19:4,636,101–4,636,717 | 54.6 kb | Distal (>10kb) Multiome | 445 | |
| chr19:4,639,001–4,640,103 | 57.6 kb | Distal (>10kb) Multiome | 710 | |
| chr19:4,669,686–4,671,221 | 88.6 kb | Distal (>10kb) Multiome | 797 | |
| chr19:4,678,652–4,679,681 | 97.4 kb | Distal (>10kb) Multiome | 164 | |
| chr19:4,723,373–4,724,832 | 142.2 kb | Distal (>10kb) Multiome | 1021 | |
| chr19:4,791,166–4,792,360 | 209.7 kb | Distal (>10kb) Multiome | 897 | |
| chr19:4,867,260–4,868,220 | 286.0 kb | Distal (>10kb) Multiome | 718 |
Genomic view of the SEMA6B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.