Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SEL1L3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEL1L3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEL1L3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:25,585,669–25,586,415 | 277.5 kb | Distal (>10kb) Multiome | 122 | |
| chr4:25,654,656–25,656,013 | 208.1 kb | Distal (>10kb) Multiome | 352 | |
| chr4:25,862,025–25,864,342 | 427 bp | At TSS Multiome | 505 | |
| chr4:25,865,717–25,865,884 | 2.7 kb | Proximal (<10kb) | 108 | |
| chr4:25,890,607–25,891,102 | 27.3 kb | Distal (>10kb) Multiome | 58 | |
| chr4:25,913,305–25,914,731 | 50.6 kb | Distal (>10kb) Multiome | 955 | |
| chr4:25,993,098–25,994,248 | 130.3 kb | Distal (>10kb) Multiome | 370 | |
| chr4:26,028,604–26,030,844 | 165.4 kb | Distal (>10kb) Multiome | 374 |
Genomic view of the SEL1L3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.