This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Transcription factors with Perturb-seq knockdown data for SCOC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCOC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCOC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:140,092,187–140,093,074 | 281.0 kb | Distal (>10kb) Multiome | 350 | |
| chr4:140,094,588–140,096,104 | 278.4 kb | Distal (>10kb) Multiome | 411 | |
| chr4:140,150,268–140,153,432 | 221.8 kb | Distal (>10kb) Multiome | 813 | |
| chr4:140,153,751–140,154,614 | 219.4 kb | Distal (>10kb) Multiome | 861 | |
| chr4:140,212,328–140,214,033 | 160.7 kb | Distal (>10kb) Multiome | 74 | |
| chr4:140,218,608–140,219,888 | 154.4 kb | Distal (>10kb) Multiome | 75 | |
| chr4:140,237,447–140,238,937 | 135.8 kb | Distal (>10kb) Multiome | 397 | |
| chr4:140,252,035–140,253,792 | 120.5 kb | Distal (>10kb) Multiome | 580 | |
| chr4:140,349,706–140,350,239 | 23.7 kb | Distal (>10kb) Multiome | 64 | |
| chr4:140,357,429–140,358,616 | 15.6 kb | Distal (>10kb) Multiome | 90 | |
| chr4:140,372,701–140,374,405 | 89 bp | At TSS Multiome | 837 | |
| chr4:140,426,688–140,428,067 | 54.0 kb | Distal (>10kb) Multiome | 896 | |
| chr4:140,497,533–140,498,453 | 124.3 kb | Distal (>10kb) Multiome | 183 | |
| chr4:140,515,302–140,516,703 | 142.7 kb | Distal (>10kb) Multiome | 90 | |
| chr4:140,523,657–140,524,734 | 150.5 kb | Distal (>10kb) Multiome | 865 | |
| chr4:140,567,710–140,569,432 | 195.4 kb | Distal (>10kb) Multiome | 331 | |
| chr4:140,594,849–140,595,496 | 221.6 kb | Distal (>10kb) Multiome | 205 | |
| chr4:140,640,083–140,640,873 | 266.8 kb | Distal (>10kb) Multiome | 115 |
Genomic view of the SCOC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.