This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SART1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SART1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SART1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,662,517–65,663,930 | 298.7 kb | Distal (>10kb) Multiome | 839 | |
| chr11:65,711,437–65,712,942 | 249.5 kb | Distal (>10kb) Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 241.1 kb | Distal (>10kb) Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 181.7 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 173.3 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 143.5 kb | Distal (>10kb) Multiome | 694 | |
| chr11:65,833,325–65,834,189 | 127.9 kb | Distal (>10kb) Multiome | 396 | |
| chr11:65,856,804–65,858,748 | 104.7 kb | Distal (>10kb) Multiome | 972 | |
| chr11:65,859,034–65,861,240 | 101.1 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:65,871,920–65,874,072 | 88.0 kb | Distal (>10kb) Multiome | 741 | |
| chr11:65,887,987–65,889,162 | 73.2 kb | Distal (>10kb) Multiome | 824 | |
| chr11:65,890,253–65,891,457 | 71.1 kb | Distal (>10kb) Multiome | 895 | |
| chr11:65,899,867–65,900,779 | 61.2 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,918,507–65,920,266 | 42.5 kb | Distal (>10kb) Multiome | 992 | |
| chr11:65,961,271–65,962,172 | 72 bp | At TSS Multiome | 834 | |
| chr11:66,001,882–66,002,962 | 40.7 kb | Distal (>10kb) Multiome | 1022 | |
| chr11:66,007,227–66,007,703 | 45.8 kb | Distal (>10kb) Multiome | 100 | |
| chr11:66,022,341–66,022,903 | 60.9 kb | Distal (>10kb) Multiome | 466 | |
| chr11:66,045,170–66,045,637 | 83.6 kb | Distal (>10kb) Multiome | 394 | |
| chr11:66,048,912–66,049,460 | 87.4 kb | Distal (>10kb) Multiome | 83 | |
| chr11:66,051,716–66,052,760 | 90.5 kb | Distal (>10kb) Multiome | 901 | |
| chr11:66,069,690–66,071,102 | 108.4 kb | Distal (>10kb) Multiome | 622 | |
| chr11:66,256,991–66,258,893 | 296.2 kb | Distal (>10kb) Multiome | 844 |
Genomic view of the SART1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.