Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPLP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPLP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPLP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:69,059,802–69,060,199 | 392.7 kb | Distal (>10kb) Multiome HiCAR | 71 | |
| chr15:69,160,021–69,161,216 | 292.3 kb | Distal (>10kb) Multiome | 783 | |
| chr15:69,290,511–69,291,221 | 161.9 kb | Distal (>10kb) Multiome | 40 | |
| chr15:69,298,371–69,299,879 | 153.9 kb | Distal (>10kb) Multiome | 345 | |
| chr15:69,413,943–69,415,079 | 38.4 kb | Distal (>10kb) Multiome | 826 | |
| chr15:69,452,178–69,453,528 | 3 bp | At TSS Multiome | 983 | |
| chr15:69,462,352–69,463,273 | 10.1 kb | Distal (>10kb) Multiome | 753 | |
| chr15:69,552,979–69,553,564 | 100.4 kb | Distal (>10kb) Multiome | 56 | |
| chr15:69,554,171–69,555,109 | 101.8 kb | Distal (>10kb) Multiome | 267 | |
| chr15:69,594,118–69,595,443 | 142.0 kb | Distal (>10kb) Multiome | 716 | |
| chr15:69,603,844–69,604,478 | 151.3 kb | Distal (>10kb) Multiome | 183 |
Genomic view of the RPLP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.