RNF220
ring finger protein 220 | FLJ10597, C1orf164

Enables beta-catenin binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and protein monoubiquitination. Located in nuclear lamina and nucleoplasm. Part of protein-containing complex. Implicated in hypomyelinating leukodystrophy 23. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 DE-4.18
Biological processes 27 terms
beta-catenin binding (GO:0008013)cytoplasm (GO:0005737)cytoplasm (GO:0005737)metal ion binding (GO:0046872)nuclear lamina (GO:0005652)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of canonical Wnt signaling pathway (GO:0090263)positive regulation of myelination (GO:0031643)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of type I interferon-mediated signaling pathway (GO:0060340)protein autoubiquitination (GO:0051865)protein binding (GO:0005515)protein monoubiquitination (GO:0006513)protein monoubiquitination (GO:0006513)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein-containing complex (GO:0032991)regulation of transcription regulatory region DNA binding (GO:2000677)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)
Expression (TPM)
RNF220 — as a Regulated Gene

TFs regulating RNF220 0 TFs

Transcription factors with Perturb-seq knockdown data for RNF220. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF220 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RNF220

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF220, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:44,134,442–44,134,897 270.5 kb Distal (>10kb) Multiome 32
chr1:44,213,251–44,213,777 191.7 kb Distal (>10kb) Multiome 1062
chr1:44,238,024–44,238,695 166.8 kb Distal (>10kb) Multiome 396
chr1:44,240,892–44,241,669 163.9 kb Distal (>10kb) Multiome 103
chr1:44,290,412–44,291,163 114.4 kb Distal (>10kb) Multiome 270
chr1:44,316,195–44,316,964 88.7 kb Distal (>10kb) Multiome 103
chr1:44,354,715–44,355,536 49.9 kb Distal (>10kb) Multiome 626
chr1:44,404,952–44,406,390 42 bp At TSS Multiome 647
chr1:44,407,412–44,408,138 2.2 kb Proximal (<10kb) 154
chr1:44,408,789–44,409,018 3.6 kb Proximal (<10kb) 120
chr1:44,417,400–44,418,123 12.4 kb Distal (>10kb) Multiome 272
chr1:44,500,703–44,501,235 95.9 kb Distal (>10kb) Multiome 128
chr1:44,512,396–44,512,984 107.5 kb Distal (>10kb) Multiome 68
chr1:44,523,679–44,524,641 119.1 kb Distal (>10kb) Multiome 302
chr1:44,542,481–44,544,064 138.1 kb Distal (>10kb) Multiome HiCAR 277
chr1:44,631,466–44,632,956 226.9 kb Distal (>10kb) Multiome 928
chr1:44,673,636–44,675,002 269.2 kb Distal (>10kb) Multiome 750

Genome Browser

Genomic view of the RNF220 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:44,124,442 – 44,685,002
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact