RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
Transcription factors with Perturb-seq knockdown data for RGMB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGMB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGMB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:96,807,053–96,808,809 | 1961.0 kb | Distal (>10kb) Multiome HiCAR | 1054 | |
| chr5:97,182,741–97,184,087 | 1585.7 kb | Distal (>10kb) Multiome HiCAR | 963 | |
| chr5:98,481,979–98,482,873 | 286.7 kb | Distal (>10kb) Multiome HiCAR | 139 | |
| chr5:98,656,235–98,657,234 | 112.6 kb | Distal (>10kb) Multiome | 134 | |
| chr5:98,742,386–98,744,121 | 25.6 kb | Distal (>10kb) Multiome | 77 | |
| chr5:98,752,174–98,753,835 | 16.6 kb | Distal (>10kb) Multiome | 226 | |
| chr5:98,763,333–98,763,579 | 5.7 kb | Proximal (<10kb) | 126 | |
| chr5:98,767,947–98,770,957 | 1.0 kb | Proximal (<10kb) Multiome | 756 | |
| chr5:98,771,374–98,771,831 | 2.1 kb | Proximal (<10kb) | 383 | |
| chr5:98,772,278–98,772,735 | 3.0 kb | Proximal (<10kb) | 118 | |
| chr5:98,772,851–98,774,947 | 4.2 kb | Proximal (<10kb) Multiome | 1033 | |
| chr5:98,927,768–98,929,898 | 159.9 kb | Distal (>10kb) Multiome | 1088 |
Genomic view of the RGMB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.