This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for RBPMS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBPMS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBPMS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:30,087,943–30,088,717 | 296.3 kb | Distal (>10kb) Multiome | 89 | |
| chr8:30,094,567–30,095,766 | 289.1 kb | Distal (>10kb) Multiome | 743 | |
| chr8:30,155,587–30,157,134 | 228.1 kb | Distal (>10kb) Multiome | 798 | |
| chr8:30,227,068–30,227,925 | 156.9 kb | Distal (>10kb) Multiome HiCAR | 398 | |
| chr8:30,339,419–30,340,356 | 44.7 kb | Distal (>10kb) Multiome | 302 | |
| chr8:30,382,201–30,382,556 | 2.0 kb | Proximal (<10kb) | 309 | |
| chr8:30,382,832–30,383,366 | 1.5 kb | Proximal (<10kb) Multiome | 188 | |
| chr8:30,383,830–30,385,512 | 8 bp | At TSS Multiome | 578 | |
| chr8:30,423,017–30,423,578 | 38.9 kb | Distal (>10kb) Multiome | 306 | |
| chr8:30,442,133–30,442,945 | 58.1 kb | Distal (>10kb) Multiome | 264 | |
| chr8:30,541,211–30,542,932 | 157.2 kb | Distal (>10kb) Multiome HiCAR | 253 | |
| chr8:30,555,639–30,556,644 | 171.5 kb | Distal (>10kb) Multiome HiCAR | 396 | |
| chr8:30,657,598–30,658,716 | 273.7 kb | Distal (>10kb) Multiome | 834 |
Genomic view of the RBPMS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.