This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for PRAG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRAG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRAG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:8,227,132–8,229,297 | 158.2 kb | Distal (>10kb) Multiome | 266 | |
| chr8:8,385,563–8,387,838 | 171 bp | At TSS Multiome | 845 | |
| chr8:8,390,004–8,392,033 | 4.8 kb | Proximal (<10kb) Multiome | 277 | |
| chr8:8,392,135–8,392,437 | 5.7 kb | Proximal (<10kb) | 5 | |
| chr8:8,408,479–8,409,016 | 22.3 kb | Distal (>10kb) Multiome | 53 | |
| chr8:8,649,084–8,649,803 | 263.0 kb | Distal (>10kb) Multiome HiCAR | 83 |
Genomic view of the PRAG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.