Predicted to enable protein phosphatase activator activity. Involved in regulation of double-strand break repair. Located in centrosome; chromatin; and nuclear speck. Part of protein phosphatase 4 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPP4R3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP4R3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP4R3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:55,418,822–55,420,474 | 197.7 kb | Distal (>10kb) Multiome | 1181 | |
| chr2:55,518,709–55,520,527 | 98.1 kb | Distal (>10kb) Multiome | 882 | |
| chr2:55,610,662–55,611,055 | 6.6 kb | Proximal (<10kb) | 34 | |
| chr2:55,616,515–55,618,979 | 139 bp | At TSS Multiome | 1070 | |
| chr2:55,620,250–55,620,479 | 2.6 kb | Proximal (<10kb) | 110 | |
| chr2:55,622,456–55,622,938 | 4.8 kb | Proximal (<10kb) | 8 | |
| chr2:55,626,227–55,626,607 | 8.6 kb | Proximal (<10kb) | 31 | |
| chr2:55,655,290–55,655,957 | 37.9 kb | Distal (>10kb) Multiome | 99 | |
| chr2:55,693,163–55,694,032 | 76.2 kb | Distal (>10kb) Multiome | 875 | |
| chr2:55,836,798–55,837,541 | 219.6 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the PPP4R3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.