Enables protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of axonogenesis; semaphorin-plexin signaling pathway; and synapse assembly. Predicted to act upstream of or within circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and kidney development. Located in lamellipodium. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLXND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLXND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLXND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:129,314,154–129,316,995 | 291.7 kb | Distal (>10kb) Multiome | 949 | |
| chr3:129,343,720–129,344,497 | 262.6 kb | Distal (>10kb) Multiome | 346 | |
| chr3:129,344,512–129,344,822 | 262.0 kb | Distal (>10kb) Multiome | 58 | |
| chr3:129,359,825–129,360,642 | 246.3 kb | Distal (>10kb) Multiome | 65 | |
| chr3:129,399,193–129,399,868 | 207.1 kb | Distal (>10kb) Multiome | 625 | |
| chr3:129,428,173–129,429,050 | 178.0 kb | Distal (>10kb) Multiome | 504 | |
| chr3:129,439,426–129,440,695 | 166.5 kb | Distal (>10kb) Multiome | 875 | |
| chr3:129,534,465–129,535,515 | 71.8 kb | Distal (>10kb) Multiome | 397 | |
| chr3:129,602,230–129,602,769 | 4.1 kb | Proximal (<10kb) Multiome | 70 | |
| chr3:129,605,081–129,607,497 | 250 bp | At TSS Multiome | 686 | |
| chr3:129,608,770–129,608,960 | 2.1 kb | Proximal (<10kb) | 204 | |
| chr3:129,610,197–129,610,485 | 3.5 kb | Proximal (<10kb) | 44 | |
| chr3:129,626,284–129,628,391 | 20.2 kb | Distal (>10kb) Multiome | 862 | |
| chr3:129,699,077–129,699,564 | 92.7 kb | Distal (>10kb) Multiome | 166 | |
| chr3:129,794,539–129,795,151 | 188.2 kb | Distal (>10kb) Multiome | 376 | |
| chr3:129,836,580–129,837,599 | 230.4 kb | Distal (>10kb) Multiome HiCAR | 170 | |
| chr3:129,892,830–129,894,307 | 287.1 kb | Distal (>10kb) Multiome HiCAR | 732 |
Genomic view of the PLXND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.