The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for PLPP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLPP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLPP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:55,307,204–55,308,263 | 227.2 kb | Distal (>10kb) Multiome | 873 | |
| chr5:55,406,222–55,406,887 | 128.5 kb | Distal (>10kb) Multiome | 40 | |
| chr5:55,484,537–55,485,441 | 50.2 kb | Distal (>10kb) Multiome | 208 | |
| chr5:55,497,392–55,498,099 | 37.2 kb | Distal (>10kb) Multiome | 88 | |
| chr5:55,534,173–55,536,366 | 68 bp | At TSS Multiome | 894 | |
| chr5:55,541,249–55,541,824 | 6.3 kb | Proximal (<10kb) | 32 | |
| chr5:55,615,856–55,616,949 | 81.5 kb | Distal (>10kb) Multiome | 117 | |
| chr5:55,625,096–55,625,790 | 90.5 kb | Distal (>10kb) Multiome | 142 | |
| chr5:55,711,869–55,712,819 | 177.4 kb | Distal (>10kb) Multiome | 772 |
Genomic view of the PLPP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.