The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for PILRB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PILRB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PILRB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,081,134–100,083,000 | 275.5 kb | Distal (>10kb) Multiome | 1160 | |
| chr7:100,088,454–100,089,460 | 268.4 kb | Distal (>10kb) Multiome | 955 | |
| chr7:100,100,270–100,102,380 | 256.7 kb | Distal (>10kb) Multiome | 1102 | |
| chr7:100,119,029–100,120,415 | 237.8 kb | Distal (>10kb) Multiome | 954 | |
| chr7:100,126,675–100,128,006 | 230.2 kb | Distal (>10kb) Multiome | 919 | |
| chr7:100,148,262–100,149,663 | 208.5 kb | Distal (>10kb) Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 198.6 kb | Distal (>10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 189.9 kb | Distal (>10kb) Multiome | 123 | |
| chr7:100,167,894–100,168,793 | 188.7 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,171,153–100,171,887 | 185.9 kb | Distal (>10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 179.8 kb | Distal (>10kb) Multiome | 626 | |
| chr7:100,266,531–100,267,045 | 90.6 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 86.7 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 85.1 kb | Distal (>10kb) Multiome | 530 | |
| chr7:100,335,652–100,336,470 | 21.3 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 24.7 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 71.6 kb | Distal (>10kb) Multiome | 1296 | |
| chr7:100,435,379–100,436,927 | 79.2 kb | Distal (>10kb) Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 93.3 kb | Distal (>10kb) Multiome | 785 | |
| chr7:100,478,582–100,479,753 | 122.0 kb | Distal (>10kb) Multiome | 842 | |
| chr7:100,482,937–100,484,533 | 126.3 kb | Distal (>10kb) Multiome | 677 | |
| chr7:100,538,557–100,539,759 | 181.7 kb | Distal (>10kb) Multiome | 858 | |
| chr7:100,542,221–100,542,986 | 185.3 kb | Distal (>10kb) Multiome | 274 | |
| chr7:100,569,177–100,570,642 | 212.2 kb | Distal (>10kb) Multiome | 855 | |
| chr7:100,585,161–100,587,241 | 229.0 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 254.9 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 269.4 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 299.0 kb | Distal (>10kb) Multiome | 653 |
Genomic view of the PILRB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.