Predicted to be located in cis-Golgi network membrane and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PHTF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHTF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHTF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,809,091–112,810,187 | 949.8 kb | Distal (>10kb) Multiome HiCAR | 445 | |
| chr1:112,819,120–112,820,730 | 940.1 kb | Distal (>10kb) Multiome HiCAR | 456 | |
| chr1:113,072,181–113,073,766 | 686.4 kb | Distal (>10kb) Multiome HiCAR | 975 | |
| chr1:113,140,616–113,141,422 | 618.5 kb | Distal (>10kb) Multiome HiCAR | 413 | |
| chr1:113,758,070–113,758,251 | 903 bp | At TSS | 89 | |
| chr1:113,758,781–113,760,075 | 8 bp | At TSS Multiome | 889 | |
| chr1:113,811,244–113,812,738 | 52.9 kb | Distal (>10kb) Multiome | 978 | |
| chr1:113,904,394–113,905,850 | 145.6 kb | Distal (>10kb) Multiome | 1025 | |
| chr1:113,929,054–113,930,528 | 170.1 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:113,938,331–113,938,852 | 179.1 kb | Distal (>10kb) Multiome | 26 | |
| chr1:113,978,866–113,979,713 | 219.8 kb | Distal (>10kb) Multiome | 426 | |
| chr1:113,999,654–114,000,118 | 240.4 kb | Distal (>10kb) Multiome | 40 | |
| chr1:114,031,872–114,032,790 | 272.8 kb | Distal (>10kb) Multiome | 88 | |
| chr1:114,037,114–114,037,804 | 277.8 kb | Distal (>10kb) Multiome | 57 |
Genomic view of the PHTF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.