Enables cadherin binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; regulation of cytoskeleton organization; and regulation of embryonic development. Located in several cellular components, including basal cortex; cytoskeleton; and focal adhesion. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PHLDB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHLDB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHLDB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:111,673,870–111,675,419 | 185.1 kb | Distal (>10kb) Multiome | 678 | |
| chr3:111,852,502–111,853,012 | 7.1 kb | Proximal (<10kb) Multiome | 110 | |
| chr3:111,853,492–111,855,490 | 4.6 kb | Proximal (<10kb) Multiome | 162 | |
| chr3:111,855,622–111,856,225 | 3.5 kb | Proximal (<10kb) | 14 | |
| chr3:111,856,980–111,857,352 | 2.4 kb | Proximal (<10kb) | 8 | |
| chr3:111,858,752–111,861,061 | 127 bp | At TSS Multiome | 807 | |
| chr3:111,862,347–111,862,979 | 2.6 kb | Proximal (<10kb) | 119 | |
| chr3:111,863,071–111,863,410 | 3.3 kb | Proximal (<10kb) | 37 | |
| chr3:111,863,555–111,863,748 | 3.8 kb | Proximal (<10kb) | 19 | |
| chr3:111,978,499–111,979,684 | 119.2 kb | Distal (>10kb) Multiome | 800 | |
| chr3:111,998,552–111,999,758 | 139.3 kb | Distal (>10kb) Multiome | 325 | |
| chr3:112,048,832–112,049,452 | 189.4 kb | Distal (>10kb) Multiome | 163 | |
| chr3:112,085,739–112,087,192 | 226.7 kb | Distal (>10kb) Multiome | 690 | |
| chr3:112,126,419–112,126,878 | 267.0 kb | Distal (>10kb) Multiome | 150 | |
| chr3:112,136,789–112,137,394 | 277.4 kb | Distal (>10kb) Multiome | 233 |
Genomic view of the PHLDB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.