PBXIP1
PBX homeobox interacting protein 1 | HPIP

The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]

Member of: DE-5 DE-5.6 Developmental clusters: GC6
Biological processes 18 terms
DNA-binding transcription factor binding (GO:0140297)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)hemopoiesis (GO:0030097)negative regulation of DNA-templated transcription (GO:0045892)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)transcription coactivator activity (GO:0003713)transcription coregulator activity (GO:0003712)transcription corepressor activity (GO:0003714)transcription regulator complex (GO:0005667)
Expression (TPM)
PBXIP1 — as a Regulated Gene

TFs regulating PBXIP1 0 TFs

Transcription factors with Perturb-seq knockdown data for PBXIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PBXIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PBXIP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PBXIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:154,558,123–154,559,826 397.3 kb Distal (>10kb) Multiome HiCAR 1173
chr1:154,683,607–154,684,346 272.1 kb Distal (>10kb) Multiome 39
chr1:154,760,465–154,760,941 195.5 kb Distal (>10kb) Multiome 418
chr1:154,813,354–154,814,052 142.5 kb Distal (>10kb) Multiome 189
chr1:154,870,031–154,870,680 85.7 kb Distal (>10kb) Multiome 300
chr1:154,936,148–154,937,752 19.1 kb Distal (>10kb) Multiome 1149
chr1:154,955,571–154,956,925 102 bp At TSS Multiome 504
chr1:154,961,269–154,962,529 5.6 kb Proximal (<10kb) Multiome 985
chr1:154,970,161–154,971,641 14.8 kb Distal (>10kb) Multiome 535
chr1:154,972,362–154,975,914 18.5 kb Distal (>10kb) Multiome 1085
chr1:154,982,968–154,983,632 27.1 kb Distal (>10kb) Multiome 693
chr1:154,998,961–155,004,423 43.2 kb Distal (>10kb) Multiome 1210
chr1:155,017,084–155,017,941 61.4 kb Distal (>10kb) Multiome 1003
chr1:155,050,292–155,052,078 95.1 kb Distal (>10kb) Multiome 948
chr1:155,061,415–155,064,552 107.8 kb Distal (>10kb) Multiome 860
chr1:155,070,748–155,071,423 115.0 kb Distal (>10kb) Multiome 542
chr1:155,078,524–155,079,535 122.7 kb Distal (>10kb) Multiome 397
chr1:155,079,852–155,081,529 124.8 kb Distal (>10kb) Multiome 539
chr1:155,084,373–155,086,501 128.9 kb Distal (>10kb) Multiome 865
chr1:155,091,315–155,091,900 135.5 kb Distal (>10kb) Multiome 594
chr1:155,126,247–155,126,903 170.4 kb Distal (>10kb) Multiome 776
chr1:155,127,607–155,128,120 171.8 kb Distal (>10kb) Multiome 578
chr1:155,135,100–155,136,750 179.7 kb Distal (>10kb) Multiome 938
chr1:155,166,847–155,168,170 211.7 kb Distal (>10kb) Multiome 622
chr1:155,172,629–155,174,979 217.2 kb Distal (>10kb) Multiome 903
chr1:155,192,921–155,194,099 237.5 kb Distal (>10kb) Multiome 755
chr1:155,194,230–155,195,403 238.8 kb Distal (>10kb) Multiome 753
chr1:155,196,127–155,196,592 240.3 kb Distal (>10kb) Multiome 97
chr1:155,207,822–155,209,789 252.9 kb Distal (>10kb) Multiome 826
chr1:155,226,522–155,227,197 270.5 kb Distal (>10kb) Multiome 600
chr1:155,227,312–155,228,116 271.6 kb Distal (>10kb) Multiome 688
chr1:155,244,103–155,245,349 288.7 kb Distal (>10kb) Multiome 900
chr1:155,250,356–155,251,199 294.7 kb Distal (>10kb) Multiome 605
chr1:155,255,032–155,255,921 299.4 kb Distal (>10kb) Multiome 661

Genome Browser

Genomic view of the PBXIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:154,548,123 – 155,265,921
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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