Predicted to enable signaling receptor activity. Predicted to be involved in oogenesis. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PAQR5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAQR5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAQR5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:69,059,802–69,060,199 | 238.9 kb | Distal (>10kb) Multiome HiCAR | 71 | |
| chr15:69,074,015–69,074,755 | 224.4 kb | Distal (>10kb) Multiome | 443 | |
| chr15:69,087,968–69,090,194 | 210.5 kb | Distal (>10kb) Multiome | 309 | |
| chr15:69,117,299–69,117,876 | 181.3 kb | Distal (>10kb) Multiome | 153 | |
| chr15:69,160,021–69,161,216 | 138.5 kb | Distal (>10kb) Multiome | 783 | |
| chr15:69,289,408–69,289,938 | 9.0 kb | Proximal (<10kb) | 93 | |
| chr15:69,290,511–69,291,221 | 8.1 kb | Proximal (<10kb) Multiome | 40 | |
| chr15:69,298,371–69,299,879 | 31 bp | At TSS Multiome | 345 | |
| chr15:69,299,995–69,300,395 | 1.0 kb | Proximal (<10kb) | 64 | |
| chr15:69,413,943–69,415,079 | 115.4 kb | Distal (>10kb) Multiome | 826 | |
| chr15:69,452,178–69,453,528 | 153.9 kb | Distal (>10kb) Multiome | 983 | |
| chr15:69,462,352–69,463,273 | 163.9 kb | Distal (>10kb) Multiome | 753 | |
| chr15:69,552,979–69,553,564 | 254.2 kb | Distal (>10kb) Multiome | 56 | |
| chr15:69,554,171–69,555,109 | 255.6 kb | Distal (>10kb) Multiome | 267 | |
| chr15:69,594,118–69,595,443 | 295.9 kb | Distal (>10kb) Multiome | 716 |
Genomic view of the PAQR5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.