Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for PALS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PALS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PALS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:24,396,244–24,396,647 | 176.8 kb | Distal (>10kb) Multiome | 38 | |
| chr7:24,426,764–24,427,450 | 146.0 kb | Distal (>10kb) Multiome | 156 | |
| chr7:24,434,873–24,435,519 | 138.1 kb | Distal (>10kb) Multiome | 150 | |
| chr7:24,464,933–24,465,440 | 108.2 kb | Distal (>10kb) Multiome | 47 | |
| chr7:24,568,827–24,569,203 | 4.1 kb | Proximal (<10kb) | 13 | |
| chr7:24,569,736–24,570,144 | 3.1 kb | Proximal (<10kb) | 22 | |
| chr7:24,572,566–24,574,418 | 25 bp | At TSS Multiome | 638 | |
| chr7:24,576,274–24,576,490 | 3.0 kb | Proximal (<10kb) | 150 | |
| chr7:24,587,958–24,588,168 | 8.9 kb | Proximal (<10kb) | 98 | |
| chr7:24,604,682–24,604,969 | 7.6 kb | Proximal (<10kb) | 37 | |
| chr7:24,725,954–24,726,590 | 153.0 kb | Distal (>10kb) Multiome | 159 | |
| chr7:24,756,703–24,758,077 | 184.2 kb | Distal (>10kb) Multiome | 609 |
Genomic view of the PALS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.