This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PACS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PACS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PACS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,779,808–65,781,988 | 290.2 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 281.9 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 252.0 kb | Distal (>10kb) Multiome | 694 | |
| chr11:65,833,325–65,834,189 | 236.5 kb | Distal (>10kb) Multiome | 396 | |
| chr11:65,856,804–65,858,748 | 213.2 kb | Distal (>10kb) Multiome | 972 | |
| chr11:65,859,034–65,861,240 | 209.7 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:65,871,920–65,874,072 | 196.6 kb | Distal (>10kb) Multiome | 741 | |
| chr11:65,887,987–65,889,162 | 181.7 kb | Distal (>10kb) Multiome | 824 | |
| chr11:65,890,253–65,891,457 | 179.6 kb | Distal (>10kb) Multiome | 895 | |
| chr11:65,899,867–65,900,779 | 169.7 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,918,507–65,920,266 | 151.0 kb | Distal (>10kb) Multiome | 992 | |
| chr11:65,961,271–65,962,172 | 108.6 kb | Distal (>10kb) Multiome | 834 | |
| chr11:66,001,882–66,002,962 | 67.9 kb | Distal (>10kb) Multiome | 1022 | |
| chr11:66,007,227–66,007,703 | 62.8 kb | Distal (>10kb) Multiome | 100 | |
| chr11:66,022,341–66,022,903 | 47.7 kb | Distal (>10kb) Multiome | 466 | |
| chr11:66,045,170–66,045,637 | 24.9 kb | Distal (>10kb) Multiome | 394 | |
| chr11:66,048,912–66,049,460 | 21.1 kb | Distal (>10kb) Multiome | 83 | |
| chr11:66,051,716–66,052,760 | 18.1 kb | Distal (>10kb) Multiome | 901 | |
| chr11:66,068,281–66,068,499 | 1.8 kb | Proximal (<10kb) | 252 | |
| chr11:66,069,690–66,071,102 | 136 bp | At TSS Multiome | 622 | |
| chr11:66,256,991–66,258,893 | 187.7 kb | Distal (>10kb) Multiome | 844 | |
| chr11:66,266,650–66,269,501 | 197.3 kb | Distal (>10kb) Multiome | 869 | |
| chr11:66,277,646–66,278,447 | 207.8 kb | Distal (>10kb) Multiome | 363 | |
| chr11:66,282,288–66,283,017 | 212.3 kb | Distal (>10kb) Multiome | 618 | |
| chr11:66,288,772–66,289,992 | 219.1 kb | Distal (>10kb) Multiome | 944 | |
| chr11:66,311,658–66,313,958 | 241.9 kb | Distal (>10kb) Multiome | 1005 | |
| chr11:66,316,861–66,317,347 | 246.8 kb | Distal (>10kb) Multiome | 164 | |
| chr11:66,328,223–66,328,781 | 258.3 kb | Distal (>10kb) Multiome | 662 | |
| chr11:66,344,804–66,345,488 | 274.9 kb | Distal (>10kb) Multiome | 731 | |
| chr11:66,347,078–66,348,463 | 277.5 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the PACS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.