The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for OAZ2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OAZ2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OAZ2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,430,220–64,430,746 | 272.8 kb | Distal (>10kb) Multiome | 350 | |
| chr15:64,460,117–64,462,256 | 241.3 kb | Distal (>10kb) Multiome | 930 | |
| chr15:64,588,906–64,589,753 | 113.9 kb | Distal (>10kb) Multiome | 112 | |
| chr15:64,634,613–64,635,221 | 68.4 kb | Distal (>10kb) Multiome | 309 | |
| chr15:64,699,707–64,700,384 | 3.1 kb | Proximal (<10kb) Multiome | 205 | |
| chr15:64,702,680–64,704,073 | 61 bp | At TSS Multiome | 747 | |
| chr15:64,774,780–64,776,025 | 72.4 kb | Distal (>10kb) Multiome | 323 | |
| chr15:64,776,175–64,776,789 | 73.4 kb | Distal (>10kb) Multiome | 105 | |
| chr15:64,780,613–64,781,099 | 77.6 kb | Distal (>10kb) Multiome | 74 | |
| chr15:64,807,123–64,808,403 | 104.7 kb | Distal (>10kb) Multiome | 248 | |
| chr15:64,808,791–64,809,297 | 105.9 kb | Distal (>10kb) Multiome | 89 | |
| chr15:64,809,806–64,810,371 | 106.9 kb | Distal (>10kb) Multiome | 298 | |
| chr15:64,823,825–64,824,470 | 120.9 kb | Distal (>10kb) Multiome | 206 | |
| chr15:64,825,130–64,826,273 | 122.6 kb | Distal (>10kb) Multiome | 784 | |
| chr15:64,840,757–64,843,201 | 138.4 kb | Distal (>10kb) Multiome | 732 | |
| chr15:64,893,790–64,894,635 | 191.0 kb | Distal (>10kb) Multiome | 506 | |
| chr15:64,905,276–64,905,958 | 202.4 kb | Distal (>10kb) Multiome | 362 | |
| chr15:64,911,481–64,912,188 | 208.6 kb | Distal (>10kb) Multiome | 308 | |
| chr15:64,915,576–64,916,281 | 212.7 kb | Distal (>10kb) Multiome | 115 | |
| chr15:64,989,345–64,990,371 | 286.7 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the OAZ2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.