A structural constituent of nuclear pore. Involved in mRNA export from nucleus and nephron development. Located in kinetochore and nuclear envelope. Part of nuclear pore outer ring. Implicated in nephrotic syndrome type 19. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NUP160. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP160 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP160, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:47,552,255–47,553,700 | 295.1 kb | Distal (>10kb) Multiome | 834 | |
| chr11:47,564,988–47,566,330 | 282.7 kb | Distal (>10kb) Multiome | 842 | |
| chr11:47,578,427–47,579,510 | 269.4 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:47,589,692–47,590,847 | 258.0 kb | Distal (>10kb) Multiome | 161 | |
| chr11:47,594,122–47,594,733 | 254.0 kb | Distal (>10kb) Multiome | 153 | |
| chr11:47,598,993–47,599,885 | 249.0 kb | Distal (>10kb) Multiome | 67 | |
| chr11:47,642,000–47,643,006 | 205.8 kb | Distal (>10kb) Multiome | 973 | |
| chr11:47,714,892–47,715,563 | 133.0 kb | Distal (>10kb) Multiome | 607 | |
| chr11:47,766,463–47,768,105 | 80.9 kb | Distal (>10kb) Multiome | 961 | |
| chr11:47,847,845–47,848,997 | 94 bp | At TSS Multiome | 863 | |
| chr11:47,916,144–47,917,140 | 68.4 kb | Distal (>10kb) Multiome | 336 | |
| chr11:47,943,718–47,944,629 | 95.8 kb | Distal (>10kb) Multiome | 269 | |
| chr11:47,979,218–47,981,637 | 132.2 kb | Distal (>10kb) Multiome | 548 | |
| chr11:48,127,687–48,128,434 | 279.9 kb | Distal (>10kb) Multiome | 97 |
Genomic view of the NUP160 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.