The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NUDT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:93,019,922–93,021,053 | 357.2 kb | Distal (>10kb) Multiome HiCAR | 563 | |
| chr12:93,022,700–93,023,746 | 354.6 kb | Distal (>10kb) Multiome HiCAR | 237 | |
| chr12:93,080,230–93,081,786 | 297.3 kb | Distal (>10kb) Multiome | 272 | |
| chr12:93,087,158–93,088,100 | 290.3 kb | Distal (>10kb) Multiome HiCAR | 624 | |
| chr12:93,106,981–93,107,741 | 270.6 kb | Distal (>10kb) Multiome HiCAR | 95 | |
| chr12:93,245,335–93,245,870 | 132.2 kb | Distal (>10kb) Multiome | 155 | |
| chr12:93,370,990–93,371,306 | 6.6 kb | Proximal (<10kb) | 67 | |
| chr12:93,376,338–93,378,831 | 46 bp | At TSS Multiome | 827 | |
| chr12:93,379,761–93,380,177 | 1.9 kb | Proximal (<10kb) | 105 | |
| chr12:93,384,690–93,385,099 | 6.8 kb | Proximal (<10kb) | 13 | |
| chr12:93,441,175–93,442,781 | 64.2 kb | Distal (>10kb) Multiome | 926 | |
| chr12:93,467,156–93,468,248 | 89.7 kb | Distal (>10kb) Multiome | 844 | |
| chr12:93,569,457–93,573,628 | 193.0 kb | Distal (>10kb) Multiome | 1052 | |
| chr12:93,677,025–93,678,145 | 299.6 kb | Distal (>10kb) Multiome | 999 |
Genomic view of the NUDT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.