This gene encodes a product belonging to a family of proteins with unknown function. The presence of two transmembrane domains suggests that this protein is a multi-pass membrane protein. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for NALF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NALF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NALF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:69,222,159–69,222,593 | 281.9 kb | Distal (>10kb) Multiome | 178 | |
| chrX:69,277,773–69,278,348 | 226.2 kb | Distal (>10kb) Multiome | 52 | |
| chrX:69,305,681–69,306,164 | 198.4 kb | Distal (>10kb) Multiome | 88 | |
| chrX:69,429,282–69,430,087 | 74.7 kb | Distal (>10kb) Multiome HiCAR | 57 | |
| chrX:69,501,466–69,501,930 | 2.4 kb | Proximal (<10kb) | 54 | |
| chrX:69,503,545–69,505,167 | 261 bp | At TSS Multiome | 392 | |
| chrX:69,563,274–69,563,876 | 59.2 kb | Distal (>10kb) Multiome | 40 | |
| chrX:69,615,731–69,617,039 | 111.7 kb | Distal (>10kb) Multiome | 405 | |
| chrX:70,133,101–70,133,613 | 629.2 kb | Distal (>10kb) Multiome HiCAR | 529 |
Genomic view of the NALF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.