The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MYDGF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYDGF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYDGF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,390,525–4,391,068 | 279.7 kb | Distal (>10kb) Multiome | 464 | |
| chr19:4,399,835–4,401,019 | 269.8 kb | Distal (>10kb) Multiome | 828 | |
| chr19:4,402,106–4,403,050 | 267.8 kb | Distal (>10kb) Multiome | 731 | |
| chr19:4,456,541–4,458,172 | 212.6 kb | Distal (>10kb) Multiome | 757 | |
| chr19:4,471,202–4,472,545 | 198.4 kb | Distal (>10kb) Multiome | 715 | |
| chr19:4,474,252–4,474,874 | 195.7 kb | Distal (>10kb) Multiome | 201 | |
| chr19:4,534,817–4,535,416 | 135.1 kb | Distal (>10kb) Multiome | 451 | |
| chr19:4,556,056–4,556,977 | 113.7 kb | Distal (>10kb) Multiome | 259 | |
| chr19:4,581,475–4,581,916 | 88.6 kb | Distal (>10kb) Multiome | 358 | |
| chr19:4,597,380–4,598,540 | 72.2 kb | Distal (>10kb) Multiome | 280 | |
| chr19:4,633,303–4,633,826 | 36.9 kb | Distal (>10kb) Multiome | 500 | |
| chr19:4,636,101–4,636,717 | 33.9 kb | Distal (>10kb) Multiome | 445 | |
| chr19:4,639,001–4,640,103 | 31.0 kb | Distal (>10kb) Multiome | 710 | |
| chr19:4,669,686–4,671,221 | 53 bp | At TSS Multiome | 797 | |
| chr19:4,677,191–4,677,403 | 6.8 kb | Proximal (<10kb) | 175 | |
| chr19:4,678,652–4,679,681 | 8.8 kb | Proximal (<10kb) Multiome | 164 | |
| chr19:4,723,373–4,724,832 | 53.6 kb | Distal (>10kb) Multiome | 1021 | |
| chr19:4,791,166–4,792,360 | 121.1 kb | Distal (>10kb) Multiome | 897 | |
| chr19:4,867,260–4,868,220 | 197.4 kb | Distal (>10kb) Multiome | 718 | |
| chr19:4,908,827–4,910,489 | 239.6 kb | Distal (>10kb) Multiome | 766 | |
| chr19:4,968,227–4,969,595 | 298.5 kb | Distal (>10kb) Multiome | 764 |
Genomic view of the MYDGF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.