Enables ATP binding activity and RNA helicase activity. Involved in DNA damage response; RNA catabolic process; and maturation of 5.8S rRNA. Located in nuclear exosome (RNase complex) and nucleoplasm. Part of TRAMP complex and catalytic step 2 spliceosome. Biomarker of amyotrophic lateral sclerosis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTREX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTREX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTREX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:55,029,649–55,030,875 | 277.6 kb | Distal (>10kb) Multiome | 91 | |
| chr5:55,172,818–55,174,056 | 134.6 kb | Distal (>10kb) Multiome | 485 | |
| chr5:55,176,186–55,176,916 | 131.4 kb | Distal (>10kb) Multiome | 520 | |
| chr5:55,220,318–55,221,200 | 87.3 kb | Distal (>10kb) Multiome | 183 | |
| chr5:55,226,323–55,227,998 | 81.3 kb | Distal (>10kb) Multiome | 708 | |
| chr5:55,232,241–55,234,359 | 74.3 kb | Distal (>10kb) Multiome | 615 | |
| chr5:55,307,204–55,308,263 | 226 bp | At TSS Multiome | 873 | |
| chr5:55,406,222–55,406,887 | 98.5 kb | Distal (>10kb) Multiome | 40 | |
| chr5:55,484,537–55,485,441 | 176.8 kb | Distal (>10kb) Multiome | 208 | |
| chr5:55,497,392–55,498,099 | 189.8 kb | Distal (>10kb) Multiome | 88 | |
| chr5:55,534,173–55,536,366 | 227.0 kb | Distal (>10kb) Multiome | 894 | |
| chr5:55,711,869–55,712,819 | 404.4 kb | Distal (>10kb) Multiome HiCAR | 772 |
Genomic view of the MTREX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.