Enables magnesium ion transmembrane transporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MRS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:24,125,708–24,127,268 | 276.8 kb | Distal (>10kb) Multiome | 676 | |
| chr6:24,359,660–24,360,414 | 42.9 kb | Distal (>10kb) Multiome | 591 | |
| chr6:24,394,145–24,394,348 | 8.6 kb | Proximal (<10kb) | 37 | |
| chr6:24,399,950–24,401,131 | 2.4 kb | Proximal (<10kb) Multiome | 381 | |
| chr6:24,402,665–24,403,713 | 24 bp | At TSS Multiome | 945 | |
| chr6:24,494,447–24,495,849 | 92.2 kb | Distal (>10kb) Multiome | 946 | |
| chr6:24,630,916–24,631,933 | 228.5 kb | Distal (>10kb) Multiome | 80 | |
| chr6:24,645,624–24,646,552 | 243.2 kb | Distal (>10kb) Multiome | 641 | |
| chr6:24,666,308–24,667,466 | 264.0 kb | Distal (>10kb) Multiome | 1037 |
Genomic view of the MRS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.