Predicted to enable metallopeptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in double-strand break repair. Predicted to be part of BRCA1-A complex and BRISC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MPND. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPND upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPND, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,064,058–4,067,782 | 277.7 kb | Distal (>10kb) Multiome | 811 | |
| chr19:4,123,681–4,124,581 | 219.4 kb | Distal (>10kb) Multiome | 798 | |
| chr19:4,182,102–4,182,890 | 161.0 kb | Distal (>10kb) Multiome | 862 | |
| chr19:4,198,066–4,198,600 | 145.3 kb | Distal (>10kb) Multiome | 214 | |
| chr19:4,246,623–4,247,617 | 96.3 kb | Distal (>10kb) Multiome | 960 | |
| chr19:4,326,625–4,329,107 | 15.1 kb | Distal (>10kb) Multiome | 567 | |
| chr19:4,342,323–4,344,016 | 638 bp | At TSS Multiome | 969 | |
| chr19:4,390,525–4,391,068 | 47.1 kb | Distal (>10kb) Multiome | 464 | |
| chr19:4,399,835–4,401,019 | 57.0 kb | Distal (>10kb) Multiome | 828 | |
| chr19:4,402,106–4,403,050 | 58.9 kb | Distal (>10kb) Multiome | 731 | |
| chr19:4,456,541–4,458,172 | 114.2 kb | Distal (>10kb) Multiome | 757 | |
| chr19:4,471,202–4,472,545 | 128.4 kb | Distal (>10kb) Multiome | 715 | |
| chr19:4,474,252–4,474,874 | 131.1 kb | Distal (>10kb) Multiome | 201 | |
| chr19:4,534,817–4,535,416 | 191.7 kb | Distal (>10kb) Multiome | 451 | |
| chr19:4,556,056–4,556,977 | 213.1 kb | Distal (>10kb) Multiome | 259 | |
| chr19:4,581,475–4,581,916 | 238.2 kb | Distal (>10kb) Multiome | 358 | |
| chr19:4,597,380–4,598,540 | 254.6 kb | Distal (>10kb) Multiome | 280 | |
| chr19:4,633,303–4,633,826 | 289.9 kb | Distal (>10kb) Multiome | 500 | |
| chr19:4,636,101–4,636,717 | 292.8 kb | Distal (>10kb) Multiome | 445 | |
| chr19:4,639,001–4,640,103 | 295.8 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the MPND locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.