Predicted to enable symporter activity. Predicted to be involved in sodium ion transport and transmembrane transport. Predicted to be located in apical plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MFSD4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFSD4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFSD4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:110,511,262–110,512,278 | 747.6 kb | Distal (>10kb) Multiome HiCAR | 164 | |
| chr6:110,981,592–110,982,485 | 277.3 kb | Distal (>10kb) Multiome | 968 | |
| chr6:111,033,760–111,034,293 | 225.3 kb | Distal (>10kb) Multiome | 47 | |
| chr6:111,087,119–111,088,655 | 171.8 kb | Distal (>10kb) Multiome | 637 | |
| chr6:111,091,616–111,092,325 | 167.5 kb | Distal (>10kb) Multiome | 90 | |
| chr6:111,251,962–111,252,726 | 7.1 kb | Proximal (<10kb) Multiome | 110 | |
| chr6:111,254,496–111,254,699 | 4.6 kb | Proximal (<10kb) | 38 | |
| chr6:111,255,604–111,255,970 | 3.4 kb | Proximal (<10kb) | 14 | |
| chr6:111,258,884–111,259,808 | 55 bp | At TSS Multiome | 945 | |
| chr6:111,477,255–111,477,926 | 218.2 kb | Distal (>10kb) Multiome | 224 | |
| chr6:111,482,095–111,484,488 | 224.3 kb | Distal (>10kb) Multiome | 1155 | |
| chr6:111,551,467–111,552,823 | 292.6 kb | Distal (>10kb) Multiome | 624 | |
| chr6:111,661,571–111,662,099 | 402.5 kb | Distal (>10kb) Multiome HiCAR | 114 | |
| chr6:111,663,255–111,663,981 | 404.4 kb | Distal (>10kb) Multiome HiCAR | 220 | |
| chr6:112,043,090–112,044,140 | 784.4 kb | Distal (>10kb) Multiome HiCAR | 680 |
Genomic view of the MFSD4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.