The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for LMTK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMTK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMTK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:97,871,662–97,873,006 | 234.4 kb | Distal (>10kb) Multiome | 963 | |
| chr7:97,927,848–97,928,741 | 178.4 kb | Distal (>10kb) Multiome | 142 | |
| chr7:97,971,853–97,972,772 | 134.7 kb | Distal (>10kb) Multiome | 763 | |
| chr7:97,973,121–97,973,850 | 133.3 kb | Distal (>10kb) Multiome | 130 | |
| chr7:98,034,095–98,034,783 | 72.3 kb | Distal (>10kb) Multiome | 131 | |
| chr7:98,051,142–98,051,601 | 55.6 kb | Distal (>10kb) Multiome | 248 | |
| chr7:98,106,660–98,107,619 | 13 bp | At TSS Multiome | 870 | |
| chr7:98,110,361–98,110,574 | 3.5 kb | Proximal (<10kb) | 63 | |
| chr7:98,110,689–98,110,897 | 3.8 kb | Proximal (<10kb) | 153 | |
| chr7:98,251,470–98,252,647 | 145.3 kb | Distal (>10kb) Multiome | 846 | |
| chr7:98,280,710–98,282,616 | 174.6 kb | Distal (>10kb) Multiome | 691 | |
| chr7:98,294,739–98,295,296 | 188.2 kb | Distal (>10kb) Multiome | 363 | |
| chr7:98,305,831–98,306,470 | 199.3 kb | Distal (>10kb) Multiome | 55 | |
| chr7:98,362,631–98,363,114 | 256.0 kb | Distal (>10kb) Multiome | 59 | |
| chr7:98,400,423–98,401,663 | 294.3 kb | Distal (>10kb) Multiome | 752 |
Genomic view of the LMTK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.