Enables protein domain specific binding activity. Predicted to be involved in neurotransmitter secretion; regulation of synaptic assembly at neuromuscular junction; and synaptic vesicle transport. Predicted to be located in plasma membrane. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LIN7B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIN7B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIN7B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:48,829,998–48,830,690 | 284.1 kb | Distal (>10kb) Multiome | 55 | |
| chr19:48,835,571–48,838,073 | 278.6 kb | Distal (>10kb) Multiome | 621 | |
| chr19:48,872,000–48,873,835 | 242.0 kb | Distal (>10kb) Multiome | 987 | |
| chr19:48,895,958–48,896,628 | 218.1 kb | Distal (>10kb) Multiome | 207 | |
| chr19:48,899,782–48,900,620 | 214.2 kb | Distal (>10kb) Multiome | 710 | |
| chr19:48,933,397–48,933,948 | 180.8 kb | Distal (>10kb) Multiome | 458 | |
| chr19:48,954,440–48,955,356 | 159.6 kb | Distal (>10kb) Multiome | 905 | |
| chr19:48,963,322–48,964,187 | 150.6 kb | Distal (>10kb) Multiome | 866 | |
| chr19:48,964,515–48,966,446 | 149.2 kb | Distal (>10kb) Multiome | 1015 | |
| chr19:48,992,571–48,994,129 | 120.9 kb | Distal (>10kb) Multiome | 852 | |
| chr19:49,017,642–49,018,292 | 96.5 kb | Distal (>10kb) Multiome | 480 | |
| chr19:49,019,277–49,019,889 | 94.8 kb | Distal (>10kb) Multiome | 233 | |
| chr19:49,055,975–49,056,714 | 58.2 kb | Distal (>10kb) Multiome | 431 | |
| chr19:49,064,668–49,065,682 | 49.3 kb | Distal (>10kb) Multiome | 226 | |
| chr19:49,071,761–49,072,903 | 42.4 kb | Distal (>10kb) Multiome | 278 | |
| chr19:49,084,646–49,086,115 | 29.1 kb | Distal (>10kb) Multiome | 1030 | |
| chr19:49,113,727–49,115,240 | 637 bp | At TSS Multiome | 746 | |
| chr19:49,118,477–49,120,300 | 4.7 kb | Proximal (<10kb) Multiome | 949 | |
| chr19:49,127,647–49,128,949 | 13.8 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:49,132,975–49,134,197 | 19.1 kb | Distal (>10kb) Multiome | 179 | |
| chr19:49,142,781–49,143,252 | 28.7 kb | Distal (>10kb) Multiome | 299 | |
| chr19:49,145,727–49,146,720 | 31.8 kb | Distal (>10kb) Multiome | 511 | |
| chr19:49,148,659–49,150,947 | 36.2 kb | Distal (>10kb) Multiome | 917 | |
| chr19:49,151,539–49,152,548 | 37.6 kb | Distal (>10kb) Multiome | 497 | |
| chr19:49,157,555–49,158,336 | 43.4 kb | Distal (>10kb) Multiome | 599 | |
| chr19:49,210,032–49,211,225 | 96.2 kb | Distal (>10kb) Multiome | 366 | |
| chr19:49,337,997–49,340,482 | 224.8 kb | Distal (>10kb) Multiome | 612 | |
| chr19:49,361,283–49,362,837 | 247.2 kb | Distal (>10kb) Multiome | 553 | |
| chr19:49,362,970–49,364,306 | 249.3 kb | Distal (>10kb) Multiome | 616 | |
| chr19:49,403,611–49,404,247 | 289.5 kb | Distal (>10kb) Multiome | 305 |
Genomic view of the LIN7B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.