The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for LDB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LDB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LDB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:16,617,871–16,618,435 | 280.4 kb | Distal (>10kb) Multiome | 59 | |
| chr4:16,890,695–16,890,949 | 7.7 kb | Proximal (<10kb) | 40 | |
| chr4:16,897,403–16,897,713 | 964 bp | At TSS | 43 | |
| chr4:16,898,083–16,899,154 | 2 bp | At TSS Multiome | 130 | |
| chr4:16,918,304–16,919,634 | 20.3 kb | Distal (>10kb) Multiome | 238 | |
| chr4:17,003,463–17,004,269 | 105.1 kb | Distal (>10kb) Multiome | 31 |
Genomic view of the LDB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.