Enables several functions, including RNA binding activity; eukaryotic initiation factor 4E binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and post-transcriptional regulation of gene expression. Located in TORC1 complex and cytoplasmic stress granule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LARP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:154,384,486–154,385,397 | 298.3 kb | Distal (>10kb) Multiome | 230 | |
| chr5:154,405,042–154,405,819 | 277.6 kb | Distal (>10kb) Multiome | 447 | |
| chr5:154,444,815–154,447,315 | 237.1 kb | Distal (>10kb) Multiome | 833 | |
| chr5:154,467,573–154,468,350 | 215.1 kb | Distal (>10kb) Multiome | 289 | |
| chr5:154,472,994–154,474,261 | 209.2 kb | Distal (>10kb) Multiome | 210 | |
| chr5:154,475,660–154,476,850 | 206.5 kb | Distal (>10kb) Multiome | 158 | |
| chr5:154,477,268–154,479,654 | 204.7 kb | Distal (>10kb) Multiome | 351 | |
| chr5:154,517,158–154,517,742 | 165.6 kb | Distal (>10kb) Multiome | 176 | |
| chr5:154,520,754–154,522,246 | 161.8 kb | Distal (>10kb) Multiome | 335 | |
| chr5:154,526,303–154,527,135 | 156.1 kb | Distal (>10kb) Multiome | 36 | |
| chr5:154,610,368–154,611,194 | 72.4 kb | Distal (>10kb) Multiome | 443 | |
| chr5:154,643,128–154,643,829 | 39.4 kb | Distal (>10kb) Multiome | 15 | |
| chr5:154,646,817–154,647,698 | 35.6 kb | Distal (>10kb) Multiome | 614 | |
| chr5:154,677,990–154,678,253 | 4.7 kb | Proximal (<10kb) | 30 | |
| chr5:154,682,263–154,683,578 | 172 bp | At TSS Multiome | 1040 | |
| chr5:154,690,578–154,690,884 | 7.6 kb | Proximal (<10kb) | 65 | |
| chr5:154,691,307–154,691,923 | 8.7 kb | Proximal (<10kb) Multiome HiCAR | 229 | |
| chr5:154,692,351–154,692,675 | 9.4 kb | Proximal (<10kb) | 156 | |
| chr5:154,712,302–154,714,063 | 29.8 kb | Distal (>10kb) Multiome | 426 | |
| chr5:154,721,510–154,721,854 | 8.7 kb | Proximal (<10kb) | 42 | |
| chr5:154,754,315–154,757,528 | 72.2 kb | Distal (>10kb) Multiome | 1020 | |
| chr5:154,811,977–154,812,153 | 590 bp | At TSS | 171 | |
| chr5:154,842,756–154,843,602 | 160.2 kb | Distal (>10kb) Multiome HiCAR | 390 | |
| chr5:154,850,234–154,850,864 | 167.7 kb | Distal (>10kb) Multiome | 450 | |
| chr5:154,857,098–154,858,937 | 175.4 kb | Distal (>10kb) Multiome | 1044 | |
| chr5:154,937,538–154,938,682 | 255.3 kb | Distal (>10kb) Multiome | 907 | |
| chr5:154,940,587–154,941,516 | 258.1 kb | Distal (>10kb) Multiome | 664 |
Genomic view of the LARP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.