The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for KIRREL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIRREL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIRREL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:126,440,475–126,441,596 | at TSS | At TSS | 367 | |
| chr11:126,606,944–126,608,877 | 395.8 kb | Distal (>10kb) Multiome HiCAR | 412 | |
| chr11:126,862,858–126,863,355 | 140.4 kb | Distal (>10kb) Multiome | 131 | |
| chr11:126,990,039–126,990,946 | 13.0 kb | Distal (>10kb) Multiome | 260 | |
| chr11:127,000,299–127,000,899 | 2.6 kb | Proximal (<10kb) | 82 | |
| chr11:127,002,851–127,004,192 | 74 bp | At TSS Multiome | 282 | |
| chr11:127,105,483–127,106,909 | 102.8 kb | Distal (>10kb) Multiome | 166 | |
| chr11:127,132,975–127,133,575 | 129.8 kb | Distal (>10kb) Multiome | 50 | |
| chr11:127,182,839–127,183,541 | 179.6 kb | Distal (>10kb) Multiome | 92 |
Genomic view of the KIRREL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.