Predicted to be involved in neuron migration. Predicted to act upstream of or within several processes, including flagellated sperm motility; proacrosomal vesicle fusion; and receptor-mediated endocytosis of virus by host cell. Located in Golgi apparatus; cytoplasmic vesicle; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIAA0319L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIAA0319L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIAA0319L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:34,792,757–34,793,260 | 764.7 kb | Distal (>10kb) Multiome HiCAR | 67 | |
| chr1:34,859,367–34,859,973 | 697.8 kb | Distal (>10kb) Multiome HiCAR | 862 | |
| chr1:34,865,980–34,866,815 | 691.2 kb | Distal (>10kb) Multiome HiCAR | 588 | |
| chr1:34,885,018–34,886,281 | 671.8 kb | Distal (>10kb) Multiome HiCAR | 254 | |
| chr1:35,191,872–35,193,675 | 365.6 kb | Distal (>10kb) Multiome HiCAR | 986 | |
| chr1:35,268,326–35,269,324 | 288.8 kb | Distal (>10kb) Multiome | 761 | |
| chr1:35,390,099–35,390,702 | 167.2 kb | Distal (>10kb) Multiome | 47 | |
| chr1:35,390,839–35,391,860 | 166.4 kb | Distal (>10kb) Multiome | 219 | |
| chr1:35,533,667–35,534,085 | 23.7 kb | Distal (>10kb) Multiome | 64 | |
| chr1:35,545,072–35,545,331 | 9.7 kb | Proximal (<10kb) | 195 | |
| chr1:35,554,954–35,555,177 | at TSS | At TSS | 47 | |
| chr1:35,556,848–35,558,023 | 7 bp | At TSS Multiome | 894 | |
| chr1:35,573,081–35,573,635 | 15.8 kb | Distal (>10kb) Multiome | 174 | |
| chr1:35,577,045–35,577,930 | 20.0 kb | Distal (>10kb) Multiome | 235 | |
| chr1:35,641,114–35,641,872 | 84.0 kb | Distal (>10kb) Multiome | 824 | |
| chr1:35,707,208–35,708,693 | 150.3 kb | Distal (>10kb) Multiome | 388 | |
| chr1:35,717,979–35,719,281 | 161.3 kb | Distal (>10kb) Multiome | 558 | |
| chr1:35,769,208–35,770,406 | 212.4 kb | Distal (>10kb) Multiome | 929 | |
| chr1:35,807,537–35,808,824 | 250.4 kb | Distal (>10kb) Multiome | 575 |
Genomic view of the KIAA0319L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.