This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KCNK5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNK5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNK5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:39,048,473–39,049,047 | 180.7 kb | Distal (>10kb) Multiome | 157 | |
| chr6:39,073,107–39,073,666 | 156.0 kb | Distal (>10kb) Multiome | 17 | |
| chr6:39,114,318–39,115,540 | 114.5 kb | Distal (>10kb) Multiome | 1049 | |
| chr6:39,117,239–39,117,843 | 112.0 kb | Distal (>10kb) Multiome | 28 | |
| chr6:39,225,603–39,225,944 | 3.5 kb | Proximal (<10kb) | 137 | |
| chr6:39,229,044–39,229,756 | 66 bp | At TSS Multiome | 626 | |
| chr6:39,233,313–39,233,532 | 3.8 kb | Proximal (<10kb) | 13 | |
| chr6:39,303,061–39,303,638 | 73.8 kb | Distal (>10kb) Multiome HiCAR | 424 | |
| chr6:39,313,260–39,314,516 | 84.2 kb | Distal (>10kb) Multiome | 156 | |
| chr6:39,362,059–39,362,807 | 132.8 kb | Distal (>10kb) Multiome | 319 |
Genomic view of the KCNK5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.