Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for JPH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JPH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JPH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:73,971,155–73,973,036 | 349.0 kb | Distal (>10kb) Multiome HiCAR | 889 | |
| chr8:73,975,889–73,976,754 | 345.1 kb | Distal (>10kb) Multiome HiCAR | 855 | |
| chr8:74,108,336–74,109,315 | 212.6 kb | Distal (>10kb) Multiome HiCAR | 221 | |
| chr8:74,115,763–74,116,601 | 205.2 kb | Distal (>10kb) Multiome HiCAR | 93 | |
| chr8:74,163,711–74,164,253 | 157.3 kb | Distal (>10kb) Multiome | 63 | |
| chr8:74,320,238–74,322,101 | 735 bp | At TSS Multiome | 590 | |
| chr8:74,330,875–74,331,280 | 9.5 kb | Proximal (<10kb) | 51 | |
| chr8:74,349,958–74,351,029 | 29.1 kb | Distal (>10kb) Multiome | 920 | |
| chr8:74,605,838–74,606,352 | 284.8 kb | Distal (>10kb) Multiome | 104 |
Genomic view of the JPH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.