This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for JCAD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JCAD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JCAD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:29,765,460–29,766,121 | 293.8 kb | Distal (>10kb) Multiome | 37 | |
| chr10:30,056,370–30,059,728 | 2.7 kb | Proximal (<10kb) Multiome | 615 | |
| chr10:30,068,640–30,069,018 | 9.1 kb | Proximal (<10kb) | 67 | |
| chr10:30,080,742–30,081,590 | 21.5 kb | Distal (>10kb) Multiome | 64 | |
| chr10:30,160,563–30,161,110 | 101.2 kb | Distal (>10kb) Multiome | 189 | |
| chr10:30,348,845–30,349,638 | 289.7 kb | Distal (>10kb) Multiome HiCAR | 582 | |
| chr10:30,359,548–30,360,380 | 300.4 kb | Distal (>10kb) Multiome | 215 |
Genomic view of the JCAD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.