This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for JAZF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JAZF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JAZF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:28,005,426–28,006,357 | 174.8 kb | Distal (>10kb) Multiome | 128 | |
| chr7:28,145,976–28,146,698 | 34.2 kb | Distal (>10kb) Multiome | 80 | |
| chr7:28,173,595–28,173,872 | 6.7 kb | Proximal (<10kb) | 19 | |
| chr7:28,179,215–28,181,152 | 826 bp | At TSS Multiome | 426 | |
| chr7:28,190,197–28,190,920 | 9.6 kb | Proximal (<10kb) | 35 | |
| chr7:28,291,502–28,292,042 | 111.1 kb | Distal (>10kb) Multiome | 132 | |
| chr7:28,369,610–28,370,318 | 189.3 kb | Distal (>10kb) Multiome | 26 | |
| chr7:28,408,254–28,410,439 | 228.6 kb | Distal (>10kb) Multiome | 489 |
Genomic view of the JAZF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.